Healing infected diabetic wounds using a nanozyme hydrogel that fights bacteria, reduces inflammation, removes harmful molecules, and produces oxygen

A multifunctional hydrogel effectively scavenged reactive oxygen species and inhibited bacterial growth in vitro.

• The hydrogel was created by combining polyvinyl alcohol and sodium alginate with graphene oxide loaded with silver-platinum nanoparticles.
• It demonstrated the ability to scavenge different types of reactive oxygen species and generate oxygen.
• Antibacterial tests indicated that the silver-platinum nanoparticles enhanced the hydrogel's effectiveness against Escherichia coli and Staphylococcus aureus compared to silver nanoparticles alone.
• The hydrogel was effective in treating infections caused by Staphylococcus aureus, promoting wound healing during the inflammatory phase.
• Hydrogel therapy significantly reduced reactive oxygen species levels and inflammation.

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