A lignocellulose-based nanocomposite hydrogel with pH-sensitive and potent antibacterial activity for wound healing

Oct 11, 2021International journal of biological macromolecules

A plant-fiber nanomaterial gel that responds to pH and strongly fights bacteria for wound healing

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Abstract

A lignocellulose-based nanocomposite hydrogel demonstrates effective wound healing properties.

The hydrogel is composed of Ag nanoparticles loaded, tannic acid-decorated lignocellulose nanofibrils mixed with sodium alginate and polyvinyl alcohol.
It exhibits excellent flexibility and self-healing abilities due to dynamic borate ester and weak hydrogen bonds.
The hydrogel's porous structure allows for effective absorption of blood and tissue exudates.
Ag nanoparticles release from the hydrogel is pH-dependent, potentially enhancing accumulation at the wound site.
In vitro tests show strong antibacterial activity against both Gram-positive (S. aureus) and Gram-negative bacteria (E. coli).
In vivo studies indicate that the hydrogel can accelerate tissue regeneration and wound healing without significant adverse effects.

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Hydrogel dressings with similar structural characteristics to the extracellular matrix and tunable physicochemical properties have become promising candidates for wound healing. However, the fabrication of an ideal hydrogel dressing with low-cost, good biocompatibility, excellent hemostatic capacity, potent and broad-spectrum antibacterial activity remains a huge challenge. Herein, a lignocellulose-based nanocomposite hydrogel (ATC/SA/PVA) is fabricated by simply mixing Ag nanoparticles loaded, tannic acid-decorated lignocellulose nanofibrils with sodium alginate and polyvinyl alcohol. Based on the dynamic borate ester bonds and multiple weak hydrogen bonds, the fabricated hydrogel exhibits excellent flexibility and self-healing performance. Its highly porous structure endows the gel excellent blood and tissue exudates absorption ability. Interestingly, the release behavior of Ag nanoparticles from hydrogel displays pH dependence, which can facilitate the accumulation of Ag nanoparticles at the wound site, thereby accelerating the process of wound healing. In vitro antibacterial assay demonstrates the potent antibacterial ability of hydrogel against both Gram-positive (S. aureus) and negative bacteria (E. coli). More importantly, in vivo investigations reveal that such hydrogel can effectively accelerate tissue regeneration and wound healing with no obvious adverse effects. All these results suggest that this nanocomposite hydrogel would be a promising candidate to accelerate wound healing.

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