Comparing telmisartan and valsartan added to amlodipine for high blood pressure not controlled in the morning

A total of 414 hypertensive patients were enrolled to evaluate the effects of valsartan and telmisartan on morning blood pressure control.

• Patients with morning systolic blood pressure between 135-159 mm Hg were randomized to receive valsartan or telmisartan for 8 weeks.
• Changes in morning systolic blood pressure after treatment were not significantly different between valsartan (-7.4 mm Hg) and telmisartan (-8.3 mm Hg).
• Valsartan was associated with increased individual variation in morning systolic blood pressure, while telmisartan did not affect this variation.
• In patients with higher baseline systolic blood pressure, telmisartan led to a significantly greater reduction in diastolic blood pressure compared to valsartan (-6.3 mm Hg vs. -3.9 mm Hg).
• These findings suggest telmisartan may be more effective than valsartan in managing morning blood pressure levels and variability.

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