Brain, behavior, and immunity

Temelimab compared to placebo in people with long COVID

Updated

Abstract

More than 400 million individuals are estimated to have been affected by post-COVID condition or long COVID.

  • Post-COVID condition can lead to greatly reduced quality of life.
  • Individuals with long COVID may experience increased personal and societal costs.
  • Temelimab is a monoclonal antibody that targets a specific viral component associated with post-COVID.
  • There is potential for Temelimab as a treatment option for post-COVID condition.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mayssam Nehme: speaking fees (Pfizer). Margret Hund-Georgiadis: no competing interest. Esther Del Corral Beamonte: no competing interest. Pierre-Olivier Bridevaux: no competing interest. Robert Hoepner: received speaker/advisor honorary from Merck, Novartis, Roche, Biogen, Alexion, Sanofi, Janssen, Bristol-Myers Squibb, Teva/Mepha and Almirall. He received research support within the last 5 years from Roche, Merck, Sanofi, Biogen, Chiesi, and Bristol-Myers Squibb. He also received research grants from the Swiss MS Society, the SITEM Insel Support Fund and is a member of the Advisory Board of the Swiss and International MS Society. He also serves as deputy editor in chief for Journal of Central Nervous System disease and is part of the ECTRIMS Young Investigator Committee. Iris-Katharina Penner: Honoraria for speaking at scientific meetings, serving at scientific advisory boards and consulting activities from Almirall, Bayer Pharma, Biogen, Celgene, Sanofi-Genzyme, Janssen, Merck, Neuraxpharm, Novartis, Roche, and Teva. Research support from the German MS Society, Celgene, Novartis, Roche, and Teva. Joana Strobel: no competing interest. Mercè Boada Rovira: no competing interest. Francesc Puchades: no competing interest. Francesco Landi: no competing interest. Pablo Guisado Vasco: Angelini Pharma Spain - consulting fees, Berlin Cures GmbH – advisory board fees, GlaxoSmithKline (Spain) - speaking fees and meetings grants, Pharma Mar SA (Spain) – speaking, consulting, meeting grants & advisory board fees, Pfizer (Spain) – speaking fees. Giovanni Guaraldi: no competing interest. Francisco Mera Cordero: no competing interest. Luca Sebastianelli: no competing interest. Loredana Sarmati: no competing interest. Nathalie Berthuy: employee of Geneuro. Jérôme Wojcik: statistician of the trial and consultant statistician for Geneuro. Karim Keddad: employee of Geneuro. Anke Post: employee of Geneuro. David Leppert: former Chief Medical Officer of Geneuro, consultant for Geneuro. Idris Guessous: member of the Fatigue Differential Diagnostic Aid (FDDA) study that was funded by CSL-Vifor.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free