Efficacy of Temozolomide Is Correlated With 1p Loss and Methylation of the Deoxyribonucleic Acid Repair Gene MGMT in Malignant Gliomas

Aug 28, 2007Neurologia medico-chirurgica

Temozolomide works better in malignant brain tumors with 1p gene loss and MGMT gene methylation

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Abstract

Promoter methylation of the MGMT gene is associated with improved outcomes in 44 patients with recurrent malignant gliomas treated with temozolomide.

  • MGMT promoter methylation correlates positively with clinical response to temozolomide therapy.
  • Loss of heterozygosity (LOH) of 1p and 19q is associated with better responses to treatment.
  • Patients with LOH of 1p and MGMT promoter methylation may experience longer progression-free survival.
  • The findings suggest that LOH of 1p could be an important predictor of treatment outcomes alongside MGMT methylation.

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