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Recurrence Pattern After Temozolomide Concomitant With and Adjuvant to Radiotherapy in Newly Diagnosed Patients With Glioblastoma: Correlation With MGMT Promoter Methylation Status
Tumor return patterns after combined chemotherapy and radiotherapy in new glioblastoma patients linked to MGMT gene methylation
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Abstract
After a median follow-up of 18.9 months, 79 patients (83%) experienced recurrence following treatment for glioblastoma.
- Recurrences were most common inside the radiotherapy field, occurring in 57 patients (72.2%).
- Seventeen patients (21.5%) had recurrences outside the radiotherapy field, while five patients (6.3%) recurred at the margin.
- MGMT methylation status was correlated with the site of recurrence, with 85% of patients with unmethylated status experiencing recurrences inside or at the margin of the radiotherapy field compared to 57.9% of those with methylated status.
- Recurrences outside the radiotherapy field occurred after a longer interval (14.9 months) compared to those inside the field (9.2 months).
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