Timing of Immune System Monitoring in Cancer: How Body Clocks Affect Cancer Defense and Treatment

Disruption of circadian rhythms is associated with impaired immune surveillance and cancer progression.

• Circadian rhythms dynamically regulate the immune system's ability to detect and combat tumors.
• Impaired immune surveillance creates an immunosuppressive environment that may promote cancer development.
• A regulatory network exists involving circadian clocks in immune cells and their influence on immune gene activity.
• Strategies for chrono-immunotherapy may include optimizing therapy timing and reprogramming circadian rhythms.
• Personalized approaches like circadian biomarkers and lifestyle adjustments could enhance precision oncology.

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