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Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
Timing of gene-silencing protein activity controlled by the body’s internal clock
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Abstract
Mouse PER complexes include the histone methyltransferase HP1γ-Suv39h.
- PER proteins recruit HP1γ-Suv39h to the Per1 and Per2 gene promoters.
- HP1γ-Suv39h is important for the circadian di- and trimethylation of histone H3 Lys9 at the Per1 promoter.
- The recruitment of HP1γ-Suv39h occurs approximately 4 hours after the recruitment of HDAC1.
- HDAC1 and HP1γ-Suv39h-containing PER complexes appear to be physically separable.
- The negative feedback mechanism of the circadian clock involves the ordered recruitment of chromatin modifiers to DNA-bound Clock-Bmal1.
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