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A Molecular Mechanism for Circadian Clock Negative Feedback
A molecular process behind the circadian clock’s self-regulation
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Abstract
PSF is identified as a key component of the PER complex that plays a role in circadian rhythm regulation.
- The three PERIOD proteins form a complex that inhibits the activity of the CLOCK-BMAL1 dimer.
- PSF recruits SIN3A to the PER complex, aiding in the assembly of transcriptional inhibitory complexes.
- The PER complex rhythmically influences the delivery of histone deacetylases to the Per1 promoter.
- This process is associated with the repression of Per1 transcription, contributing to the negative feedback mechanism of the circadian clock.
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