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Metastasis-associated protein 1 is an integral component of the circadian molecular machinery
Metastasis-associated protein 1 is a key part of the body's internal clock system
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Abstract
Knockout of MTA1 in mice disrupts the free-running period of circadian rhythms under constant light.
- MTA1 is a gene product that is widely upregulated in human cancers.
- The CLOCK-BMAL1 protein complex activates MTA1 transcription via a specific region in its promoter.
- MTA1 interacts with CLOCK-BMAL1 and promotes its own transcription as well as that of another clock gene, CRY1.
- MTA1 influences the deacetylation of BMAL1, which impacts the negative feedback mechanism of the circadian clock.
- These findings suggest that MTA1 plays a crucial role in regulating circadian rhythms.
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