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Abstract
A comprehensive analysis of the gonadal transcriptome reveals tissue-specific mechanisms of reproductive aging associated with .
- Age-related decline in reproductive function is a significant aspect of aging.
- Reduced insulin/IGF-1 signaling extends the reproductive span in the model organism Caenorhabditis elegans.
- Prior research has focused on isolated tissues or specific time points rather than comprehensive temporal analysis.
- This study compares the gonadal transcriptome with somatic tissues to identify unique regulatory mechanisms.
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