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The Role of TFEB-Regulated Autophagy in Intervertebral Disc Degeneration and Its Therapeutic Potential
How Cell Recycling Controlled by TFEB May Affect Spinal Disc Degeneration and Treatment
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Abstract
(TFEB) is identified as a pivotal player in intervertebral disc degeneration (IVDD).
- Intervertebral disc degeneration (IVDD) is associated with nucleus pulposus cell (NPC) senescence, extracellular matrix imbalance, and chronic inflammation.
- TFEB regulates and lysosomal biogenesis, promoting the removal of damaged cellular components in NPCs.
- Dysfunction of TFEB may impair autophagic processes, leading to increased cellular death, oxidative stress, and degradation of the extracellular matrix.
- TFEB is positioned as a crucial therapeutic target for addressing the underlying mechanisms of IVDD.
- The review evaluates potential TFEB-targeted strategies and highlights key challenges in translating these approaches into clinical therapy.
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