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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
TFEB regulates cell fat metabolism through a self-control loop activated by starvation
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Abstract
Starvation induces the transcription factor EB (TFEB), which plays a crucial role in lipid catabolism and cellular energy metabolism.
- The lysosomal-autophagic pathway is activated by starvation, aiding in cellular clearance and lipid breakdown.
- TFEB is induced during starvation through an autoregulatory feedback loop.
- TFEB exerts global transcriptional control over lipid catabolism via specific genes.
- This transcriptional mechanism linking autophagy and energy metabolism may be conserved across species, as indicated by studies in Caenorhabditis elegans.
- Viral delivery of TFEB to the liver has shown potential in preventing weight gain and metabolic syndrome in mouse models of obesity.
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