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Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
Higher resting activity in the brain’s relay center linked to LSD hallucinations
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Abstract
LSD administration significantly increased thalamic functional connectivity to various cortical regions.
- Alterations were observed across all dimensions of the following LSD administration.
- Increased thalamic connectivity was specifically noted with regions associated with auditory and visual hallucinations.
- Significant correlations were found between thalamic connectivity to the right fusiform gyrus and insula and subjective visual and auditory effects of the drug.
- These findings may suggest that hallucinogenic drug effects are linked to enhanced cortical excitability through interactions within the thalamocortical system.
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Key numbers
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Increased Thalamic Connectivity
Significant connectivity increase between thalamus and brain regions under LSD vs. placebo.
1.3 ± 0.6 ng/ml
Plasma LSD Level at 2h
Mean plasma concentration of LSD measured 2 hours after administration.