The daily rhythm in airway cells controls timing of immune cell movement in chronic allergic lung disease

Allergic asthma patients experience distinct temporal variations in symptoms across a 24-hour period.

• The molecular circadian clock is important for regulating responses to allergens in mice.
• Club cells in the lungs play a role in managing time-dependent reactions to inflammatory stimuli.
• In mice lacking a functional circadian clock in the lungs, patterns of eosinophil and T-helper 2 cell movement are disrupted.
• Circadian rhythms in airway permeability are lost in club cell specific Bmal1 knockout mice, leading to uniform cell trafficking at all times.

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