The effects of adjuvant arthritis on the myometrial adrenergic functions in the nonpregnant and the late-pregnant rat.
How arthritis affects nerve control of uterine muscle in nonpregnant and late-pregnant rats
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Abstract
Adjuvant arthritis substantially decreased the uptake and release of [(3)H]noradrenaline in myometrial samples from nonpregnant rats.
- In nonpregnant rats, inflammation from adjuvant arthritis negatively affected adrenergic functions in the uterus.
- Both nonpregnant and late pregnant rats showed decreased electrically induced uterine contractions due to inflammation.
- Inflammation resulted in reduced relaxation mediated by β-adrenoceptors in both gestational states.
- At term, arthritis led to increased contractions mediated by α-adrenoceptors.
- The findings suggest that the adrenergic innervation of the uterus is impaired by adjuvant arthritis.
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