Thiamine ameliorates metabolic disorders induced by a long-term high-concentrate diet and promotes rumen epithelial development in goats

Dietary thiamine supplementation at 200 mg/kg of dry matter intake significantly increased concentrations of various metabolites in goats fed a high-concentrate diet.

• Thiamine supplementation is associated with improved rumen epithelium inflammation and barrier function.
• Increased levels of important metabolites such as d-glucose 6-phosphate and acetyl-CoA were observed in the thiamine-supplemented group compared to the high-concentrate group.
• Higher enzyme activities related to carbohydrate metabolism were recorded in the thiamine-supplemented goats.
• The plasma total antioxidant capacity was greater in the thiamine group, indicating enhanced antioxidant status.
• Rumen epithelium ATP content was elevated in the thiamine group, suggesting improved energy status.
• Lower mRNA levels of key cell cycle and growth regulation genes were found in the high-concentrate group, indicating potential disruptions in growth signaling.

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