Stimulus properties of tiflucarbine: A novel antidepressant agent

Dec 1, 1990Pharmacology, biochemistry, and behavior

Effects of tiflucarbine, a new antidepressant drug, on brain responses

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Abstract

Tiflucarbine resulted in stimulus generalization in 10 mg/kg-treated animals trained with a nonselective 5-HT agonist.

Tiflucarbine binds at central serotonin (5-HT) binding sites.
It acts as both a 5-HT1 and a 5-HT2 agonist.
Partial generalization was observed in rats trained with the 5-HT1A agonist and the 5-HT2 agonist.
About two-thirds of the animals showed disrupted behavior in response to tiflucarbine.
Overall, tiflucarbine is likely a nonselective 5-HT agonist.

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Tiflucarbine is a structurally novel antidepressant that binds at central serotonin (5-HT) binding sites. There is also evidence that this agent is both a 5-HT1 and a 5-HT2 agonist. To further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-HT1A agonist 8-OH DPAT, the 5-HT2 agonist DOM, and the nonselective 5-HT agonist 5-OMe DMT from saline. Tiflucarbine resulted in partial generalization in the DOM-trained and in the 8-OH DPAT-trained animals. Although two-thirds of the animals were disrupted, 10 mg/kg of tiflucarbine resulted in stimulus generlization in the 5-OMe DMT-trained animals. It is concluded that tiflucarbine is most likely a nonselective 5-HT agonist.

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Stimulus properties of tiflucarbine: A novel antidepressant agent

Abstract

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