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Abstract
Tilianin significantly reduced myocardial infarction in a rat model of ischemia/reperfusion injury.
- Treatment with Tilianin improved the pathological structure of the heart tissue.
- Tilianin markedly increased ATP and NAD levels while decreasing ADP and AMP levels.
- The ratio of AMP to ATP was reduced following Tilianin treatment.
- Tilianin lowered levels of reactive oxygen species (ROS) and malondialdehyde (MDA), indicating reduced oxidative stress.
- Enhanced activity of superoxide dismutase (SOD) was observed with Tilianin treatment.
- Expression levels of AMPK, SIRT1, and PGC-1 alpha mRNA were significantly elevated by Tilianin.
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