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Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock
Timed release of liver proteins shows how the liver’s daily clock controls hormone-like signals
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Abstract
The liver secretes more endostatin during the inactive, fasting phase of the diurnal cycle.
- Hundreds of proteins are identified that show time-of-day-dependent secretion related to various bodily functions.
- The secretion of endostatin, derived from collagen type XVIII alpha 1, increases during fasting.
- Loss of Bmal1 disrupts the regulation of COL18A1 and endostatin levels through changes in gene expression and protein processing.
- Endostatin may suppress mitochondrial gene expression and respiration in white adipose tissue while promoting lipolysis.
- These findings suggest a mechanism where endostatin from the liver influences metabolic processes in adipose tissue during fasting.
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