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The liver clock modulates circadian rhythms in white adipose tissue
The liver's internal clock influences daily rhythms in body fat tissue
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Abstract
Hepatic circadian control may modulate lipid metabolism in white adipose tissue (WAT).
- The liver clock plays a central role in regulating circadian rhythms in WAT.
- A hepatocyte-specific Bmal1 knockout mouse model indicates the liver clock can integrate feeding cues to influence gene expression in WAT.
- Cebpa, a key regulator of fat cell formation, shows rhythmicity in response to hepatic circadian signals.
- Secreted proteins from the hepatocyte clock are involved in regulating the rhythmic expression of Cebpa in adipocytes.
- Human cohort data suggest a gene regulatory network in the liver that is associated with cardiometabolic risk.
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