Tirzepatide and Leptin Work Together to Promote Weight Loss and Improve Metabolism in Diet-Induced Obesity
Updated
Abstract
Circulating leptin levels at baseline correlated with weight loss efficacy in patients with obesity treated with tirzepatide.
- Tirzepatide, a dual-agonist, may enhance leptin sensitivity, which is often diminished in obesity.
- Combining tirzepatide with leptin (TZP+Lep) showed synergistic effects on weight loss in diet-induced obesity mice.
- TZP+Lep treatment improved insulin sensitivity and increased specific gene expression related to thermogenesis in brown adipose tissue.
- Metabolic profiling indicated that TZP+Lep reduced food intake and increased energy expenditure in treated subjects.
- Tirzepatide sensitized leptin signaling in specific neurons associated with appetite regulation and energy balance.
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Funding
Competing interests
Duality of Interest. M.S., B.A.D, Y.L, J.M.W., P.F.C., R.J.S. and M.A. are current employees of Eli Lilly. No other potential conflicts of interest relevant to this article were reported.
PubMed