ACG case reports journal

Rare Liver Damage Linked to the Medication Tirzepatide

Updated

Abstract

A 76-year-old woman developed acute hepatitis after 8 weeks of tirzepatide use, coinciding with a sixteen-pound weight loss.

  • Tirzepatide is an injectable medication for type 2 diabetes and obesity.
  • There are few reported cases of (DILI) associated with tirzepatide.
  • The patient exhibited elevated liver enzymes, indicating liver dysfunction.
  • Liver biopsy confirmed the diagnosis of DILI.
  • The mechanism behind this liver injury is currently unknown.
  • Awareness of this rare side effect is important for healthcare providers.

Simplified

Key numbers

486 U/L
Alanine Aminotransferase Level
Measured during acute presentation after 8 weeks on tirzepatide.
515 U/L
Aspartate Aminotransferase Level
Documented alongside elevated alanine aminotransferase.
16 pounds
Weight Loss
Reported at the time of acute hepatitis presentation.

Full Text

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