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Efficacy of tirzepatide 5, 10 and 15 mg versus semaglutide 2 mg in patients with type 2 diabetes: An adjusted indirect treatment comparison
Effectiveness of different doses of tirzepatide compared to semaglutide in type 2 diabetes patients
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Abstract
Tirzepatide 10 and 15 mg significantly reduced HbA1c by 0.36% and 0.40%, respectively, compared to semaglutide 2 mg.
- Tirzepatide 10 mg was associated with a reduction in body weight of -3.15 kg compared to semaglutide 2 mg.
- Tirzepatide 15 mg resulted in a body weight reduction of -5.15 kg compared to semaglutide 2 mg.
- No significant differences were observed between tirzepatide 5 mg and semaglutide 2 mg for changes in HbA1c and body weight.
- The analysis included data from 238 to 240 participants for tirzepatide and 240 participants for semaglutide.
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Key numbers
-0.36%
Decrease in HbA1c with tirzepatide 10 mg
Estimated treatment difference vs. semaglutide 2 mg
-5.15 kg
Decrease in body weight with tirzepatide 15 mg
Estimated treatment difference vs. semaglutide 2 mg