Tissue-specific BMAL1 binding shows rhythmic gene activity linked to rhythmic enhancer interactions

BMAL1 DNA binding is largely tissue-specific, influenced by differences in chromatin accessibility.

• Rhythmic gene expression driven by the circadian clock varies between different tissues.
• Differences in chromatin accessibility and tissue-specific transcription factors affect BMAL1's binding.
• The ability of BMAL1 to regulate tissue-specific rhythmic transcription is linked to both BMAL1-bound enhancers and neighboring enhancers.
• Physical interactions between BMAL1 enhancers and regulatory regions are characterized by chromatin interaction analysis.
• There is a correlation between rhythmic expression of BMAL1 target genes and rhythmic chromatin interactions.

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