TOCOLYTIC EFFECT OF PARECOXIB, A NEW PARENTERAL CYCLO‐OXYGENASE‐2‐SPECIFIC INHIBITOR, ON THE SPONTANEOUS AND PROSTAGLANDIN‐INDUCED CONTRACTIONS OF RAT ISOLATED MYOMETRIUM

Parecoxib caused 84% inhibition of spontaneous uterine contractions at 600 micromol/L.

• Application of parecoxib resulted in dose-dependent decreases in contractility of uterine smooth muscle.
• Mean percentage inhibition of spontaneous contractions was 29%, 56%, 74%, and 84% at 50, 150, 300, and 600 micromol/L, respectively.
• For prostaglandin-induced contractions, parecoxib caused 27%, 43%, 61%, and 73% inhibition at 100, 300, 600, and 900 micromol/L, respectively.
• Pretreatment with parecoxib reduced responsiveness and maximum contractility to prostaglandin compared to untreated strips.
• These findings indicate that parecoxib inhibits both spontaneous and prostaglandin-induced contractions in rat myometrium.

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