Magnesium reduces natural and triggered contractions in isolated uterine muscle

Magnesium sulfate reduced spontaneous myometrial contractions by up to 100% at a concentration of 3 mM.

• The relaxant effect of magnesium sulfate on myometrial contractions was observed in both pregnant and non-pregnant women.
• Spontaneous contractions decreased in a dose-dependent manner, with significant reductions at concentrations of 2.0-2.5 mM.
• Oxytocin-induced contractions were reduced by 30-40% at an 8 mM concentration, with further reductions at higher concentrations.
• Maximum effects on induced contractions were noted at 20 minutes, indicating both dose and time dependency.
• No significant differences were found in the response of pregnant versus non-pregnant myometrium.

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