Full text is available at the source.
Abstract
Non-neuronal cells in the cortex adjust gene expression significantly during the seasonal transition from summer to winter.
- Cortical neurons show major transcriptional changes during daily torpor, with increased activity in RNA breakdown processes.
- Differential gene expression related to circadian rhythms was observed primarily in non-neuronal cells during seasonal changes.
- Distinct transcriptional programs were identified between the cortex and hypothalamus, indicating region-specific adaptations.
- These findings suggest that different cell types in the brain adapt uniquely to conserve energy during extreme conditions.
Simplified