The European journal of neuroscience

Rats with altered BMAL1 gene show weaker body clock rhythms and faster adjustment to jet lag

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Transgenic rats expressing a modified form of BMAL1 showed smaller circadian rhythm amplitudes compared to control rats.

  • The transgenic rats became active earlier after light offset than control rats.
  • A light pulse at night caused a larger phase shift in the behavioral rhythm of the transgenic rats.
  • Transgenic rats demonstrated faster adaptation to new light-dark cycles following abrupt shifts compared to controls.
  • Results suggest that altering the amplitude of circadian rhythms may influence the duration of phase shifts.

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