Transgenic rats expressing dominant negative BMAL1 showed circadian clock amplitude reduction and rapid recovery from jet lag

Dec 22, 2020The European journal of neuroscience

Rats with altered BMAL1 gene show weaker body clock rhythms and faster adjustment to jet lag

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Abstract

Transgenic rats expressing a modified form of BMAL1 showed smaller circadian rhythm amplitudes compared to control rats.

  • The transgenic rats became active earlier after light offset than control rats.
  • A light pulse at night caused a larger phase shift in the behavioral rhythm of the transgenic rats.
  • Transgenic rats demonstrated faster adaptation to new light-dark cycles following abrupt shifts compared to controls.
  • Results suggest that altering the amplitude of circadian rhythms may influence the duration of phase shifts.

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