Arginine vasopressin signals in the brain’s circadian center and their role in resisting jet lag

Arginine vasopressin/V1 receptor signaling in the suprachiasmatic nucleus is critical for the circadian clock's resilience to jet lag.

• Almost all organisms possess a circadian clock that regulates various biological functions with a roughly 24-hour cycle.
• In mammals, the master pacemaker of this clock is located in the suprachiasmatic nucleus (SCN) of the brain.
• Jet lag disrupts the alignment of circadian rhythms due to sudden changes in light-dark cycles.
• The study highlights the importance of SCN signaling mechanisms in maintaining circadian function during jet lag.
• A model of the SCN neuronal system under jet lag conditions is discussed, illustrating these processes.

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