Peptides

Arginine vasopressin as an important regulator of the body’s daily biological rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Arginine vasopressin (AVP) is crucial for maintaining circadian homeostasis in mammals.

  • The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms composed of various cell types.
  • AVP plays a significant role in the function of circadian rhythms, as demonstrated in studies with genetically engineered mice.
  • The review discusses the distribution of AVP-expressing neurons and their organization within the SCN.
  • Sex-dependent effects of AVP in the SCN may influence circadian rhythm regulation.
  • Research indicates that AVP receptor knockout mice provide insights into the physiological roles of AVP in circadian regulation.
  • Genetic modifications of AVP neurons suggest potential pathways for therapeutic interventions targeting circadian disruptions.

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Funding

Competing interests

Declaration of Competing Interest The author Yoshiaki Yamaguchi declares that he has no conflicts of interest.
PubMed

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