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GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior
GABA from vasopressin neurons controls when the brain’s circadian clock triggers daily behaviors
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Abstract
Mice with a specific deletion of the vesicular GABA transporter in arginine vasopressin (AVP)-producing neurons exhibited significant impairment of circadian rhythms.
- Circadian behavioral rhythms were marked by a lengthened activity time due to extended intervals between morning and evening activities.
- Diurnal rhythms of GABA receptor-mediated synaptic transmission in suprachiasmatic nucleus (SCN) neurons were disturbed.
- The phase relationships between molecular clocks in the SCN and circadian locomotor activities were significantly altered.
- Mice displayed a bimodal pattern of daily neuronal activity in SCN neurons that correlated with the dissociated morning and evening locomotor activities.
- GABAergic transmission from AVP neurons may regulate the timing of SCN neuronal firing to align circadian behavior with appropriate time windows.
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