Proceedings of the National Academy of Sciences of the United States of America

GABA from vasopressin neurons controls when the brain’s circadian clock triggers daily behaviors

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mice with a specific deletion of the vesicular GABA transporter in arginine vasopressin (AVP)-producing neurons exhibited significant impairment of circadian rhythms.

  • Circadian behavioral rhythms were marked by a lengthened activity time due to extended intervals between morning and evening activities.
  • Diurnal rhythms of GABA receptor-mediated synaptic transmission in suprachiasmatic nucleus (SCN) neurons were disturbed.
  • The phase relationships between molecular clocks in the SCN and circadian locomotor activities were significantly altered.
  • Mice displayed a bimodal pattern of daily neuronal activity in SCN neurons that correlated with the dissociated morning and evening locomotor activities.
  • GABAergic transmission from AVP neurons may regulate the timing of SCN neuronal firing to align circadian behavior with appropriate time windows.

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Competing interests

The authors declare no competing interest.
PubMed

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