Neuron

Cellular clocks in specific brain cells help coordinate daily behavior rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mice with a deletion of the Bmal1 gene specific to vasopressin-producing neurons displayed a marked lengthening in free-running period and activity time of behavior rhythms.

  • These mice reentrained faster than control mice after a sudden 8-hour shift in the light/dark cycle.
  • Circadian expression of genes related to cell communication was drastically reduced in the dorsal suprachiasmatic nucleus (SCN), where vasopressin neurons are dominant.
  • Dorsal SCN cells exhibited lower oscillation of the PER2::LUC protein with increased variability and longer periods.
  • Bmal1-dependent oscillators in vasopressin neurons may influence how the SCN network synchronizes morning and evening behavioral rhythms.

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