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Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus
Timing and location of arginine vasopressin gene activity in the brain's internal clock cells in culture
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Abstract
Heterozygous AVP(ELuc/+) mice exhibited robust circadian rhythms in arginine vasopressin expression over more than 10 cycles.
- AVP is believed to play a key role in regulating the body's internal clock.
- Real-time monitoring of AVP transcription was achieved using a bioluminescence reporter system.
- Circadian behavior rhythms and light responsiveness in AVP(ELuc/+) mice were similar to wild-type mice.
- Stable circadian rhythms in AVP expression were observed at both single-cell and tissue levels within the suprachiasmatic nucleus.
- Rhythmicity of AVP expression in other hypothalamic regions was less stable and diminished quickly.
- Analysis showed significant variations in circadian rhythms among different clusters of AVP-positive cells.
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