Links between blood fat-sugar measures and overall and specific causes of death in the general population

Adjusted hazard ratios for all-cause mortality in the highest quartile of the triglyceride-glucose index were 1.26 compared to the lowest quartile.

• A progressive increase in all-cause and cause-specific mortality was observed across quartiles of the triglyceride-glucose indices.
• The highest quartile of the triglyceride-glucose index was associated with hazard ratios of 1.38 for cardiovascular mortality and 1.23 for non-cardiovascular mortality.
• For the triglyceride-glucose combined with waist-to-height ratio index, hazard ratios were 1.86 for cardiovascular mortality and 1.48 for non-cardiovascular mortality.
• The triglyceride-glucose combined with waist circumference index showed hazard ratios of 1.48 for cardiovascular mortality and 1.38 for non-cardiovascular mortality.
• The associations between the triglyceride-glucose indices and mortality were J-shaped, indicating varying risk levels at different index values.
• Significant interactions were found with age, low-density lipoprotein cholesterol levels, and statin use, suggesting potential modifiers of mortality risk.

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