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Association between triglyceride-glucose related indices and all-cause and cause-specific mortality in the general population: a cohort study
Links between blood fat-sugar measures and overall and specific causes of death in the general population
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Abstract
Adjusted hazard ratios for all-cause mortality in the highest quartile of the triglyceride-glucose index were 1.26 compared to the lowest quartile.
- A progressive increase in all-cause and cause-specific mortality was observed across quartiles of the triglyceride-glucose indices.
- The highest quartile of the triglyceride-glucose index was associated with hazard ratios of 1.38 for cardiovascular mortality and 1.23 for non-cardiovascular mortality.
- For the triglyceride-glucose combined with waist-to-height ratio index, hazard ratios were 1.86 for cardiovascular mortality and 1.48 for non-cardiovascular mortality.
- The triglyceride-glucose combined with waist circumference index showed hazard ratios of 1.48 for cardiovascular mortality and 1.38 for non-cardiovascular mortality.
- The associations between the triglyceride-glucose indices and mortality were J-shaped, indicating varying risk levels at different index values.
- Significant interactions were found with age, low-density lipoprotein cholesterol levels, and statin use, suggesting potential modifiers of mortality risk.
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Key numbers
1.26
Increase in All-Cause Mortality Risk
Hazard ratio for quartile 4 vs. quartile 1
1.60
Increase in All-Cause Mortality Risk (TyG-WHtR)
Hazard ratio for TyG-WHtR index quartile 4 vs. quartile 1
27,642
Study Population
Total number of individuals included in the analysis