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TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice
TUDCA, a bile acid, reduces harmful protein buildup linked to Alzheimer's in a mouse model
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Abstract
Feeding APP/PS1 double-transgenic mice a diet containing 0.4% TUDCA for 6 months reduced accumulation of amyloid-β deposits in the brain.
- TUDCA treatment markedly improved memory deficits in APP/PS1 mice.
- Reduced glial activation and loss of neuronal integrity were observed in TUDCA-fed mice compared to untreated counterparts.
- TUDCA influenced lipid-metabolism mediators linked to amyloid-β production and accumulation in the brain.
- Overall amyloidogenic processing of APP was reduced with TUDCA treatment, which may involve modulation of γ-secretase activity.
- Significant decreases in levels of Aβ(1-40) and Aβ(1-42) were found in the hippocampus and frontal cortex of treated mice.
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