Targeting tumor-associated macrophages as an antitumor strategy

The number of tumor-associated macrophages (TAMs) is closely correlated with poor outcomes in multiple cancers.

• TAMs play complex roles in tumor development, including supporting blood vessel formation, enhancing tumor spread, and creating an environment that suppresses the immune response.
• Strategies targeting TAMs may involve blocking signals that promote blood vessel growth, inhibiting immune checkpoints, or enhancing the ability of macrophages to engulf tumor cells.
• Some TAM-targeted treatments have demonstrated promising results when used alone or in combination with chemotherapy or immunotherapy in clinical trials.
• A novel approach involves equipping macrophages with CAR molecules to potentially improve treatment effectiveness for solid tumors.
• Despite positive findings, additional research is necessary to fully understand TAM functions and to develop more effective cancer therapies.

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