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Targeting tumor-associated macrophages for cancer immunotherapy
Using Immune Cells Around Tumors to Improve Cancer Treatment
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Abstract
Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment and are associated with tumor growth.
- TAMs promote strong blood vessel formation in tumors and support the survival of tumor cells.
- Reducing the density or effects of TAMs may inhibit tumor growth.
- TAMs are being investigated as targets for cancer immunotherapy.
- Various clinical and preclinical trials are studying drugs that inhibit the effects of TAMs.
- The paper summarizes methods for targeting TAMs, including their mechanisms and polarization.
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