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Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2
Ubiquitin enzyme E2S reduces glioblastoma cell response to temozolomide by increasing PGAM1 through interaction with OTUB2
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Abstract
UBE2S is overexpressed in GBM cells, impacting their sensitivity to temozolomide (TMZ).
- UBE2S interacts with phosphoglycerate mutase 1 (PGAM1) and Otubain-2 (OTUB2).
- This interaction inhibits the degradation of PGAM1, leading to increased levels of the protein.
- Higher PGAM1 levels are associated with enhanced DNA repair capabilities in GBM cells.
- Increased DNA repair may contribute to reduced apoptosis in response to TMZ treatment.
- The findings suggest that targeting UBE2S could improve the effectiveness of TMZ against GBM.
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