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Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells
Ubiquitin ligase TRAF2 reduces core clock protein BMAL1 activity and lowers peak Per1 gene levels in the cellular circadian clock
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Abstract
TRAF2 interacts with BMAL1 to reduce its stability through ubiquitination and degradation.
- BMAL1 is a key regulator of the circadian clock and influences various biological processes.
- TRAF2 is identified as an E3 ubiquitin ligase that interacts with BMAL1.
- The interaction between TRAF2 and BMAL1 occurs primarily through the zinc finger domain of TRAF2.
- TRAF2 expression decreases the transcriptional activity of BMAL1.
- Knockdown of Traf2 increases the maximum level of Per1 mRNA in a neuroblastoma cell line.
- This study highlights TRAF2 as a novel regulatory factor for BMAL1.
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