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Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila
Role of the cell protein recycling system in daily biological clocks and sleep regulation from studies in fruit flies
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Abstract
The circadian clock in Drosophila is regulated by post-translational modifications and degradation of core clock proteins through the .
- Circadian rhythms are well understood at the molecular level in Drosophila.
- Post-translational modifications play a key role in regulating core clock proteins.
- The ubiquitin-proteasome system is involved in the degradation of these proteins.
- Proteasome-mediated degradation may influence both circadian clock regulation and sleep amount.
- E3 ubiquitin ligases could interact with mechanisms regulating circadian and homeostatic sleep.
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