Umbelliferone may reduce memory problems caused by sleep loss by changing gut bacteria

UMB treatment significantly improved learning and memory performance in mice subjected to sleep deprivation.

• Sleep deprivation is associated with cognitive impairment, central neuroinflammation, and altered gut microbiota.
• The tryptophan pathway, activated by indoleamine 2,3-dioxygenase, links immune activation to neuronal damage.
• UMB treatment restored gut microbiota composition and levels of short-chain fatty acids.
• UMB inhibited the expression of indoleamine 2,3-dioxygenase and rebalanced tryptophan-kynurenine metabolism.
• Treatment with UMB reduced pro-inflammatory cell release and oxidative stress while suppressing astrocyte and microglial activation.

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