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Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota
Umbelliferone may reduce memory problems caused by sleep loss by changing gut bacteria
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Abstract
UMB treatment significantly improved learning and memory performance in mice subjected to sleep deprivation.
- Sleep deprivation is associated with cognitive impairment, central neuroinflammation, and altered gut microbiota.
- The tryptophan pathway, activated by indoleamine 2,3-dioxygenase, links immune activation to neuronal damage.
- UMB treatment restored gut microbiota composition and levels of short-chain fatty acids.
- UMB inhibited the expression of indoleamine 2,3-dioxygenase and rebalanced tryptophan-kynurenine metabolism.
- Treatment with UMB reduced pro-inflammatory cell release and oxidative stress while suppressing astrocyte and microglial activation.
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