Higher uric acid to HDL cholesterol ratio was linked to faster in NHANES adults.
Evidence
This adjusted observational cohort analysis of NHANES 2009-2018 related , uric acid, and HDL cholesterol to PhAA and KDM-AA with regression, spline, subgroup, and interaction analyses.
Caveat
The study is observational, so UHR may mark metabolic risk rather than directly cause accelerated biological aging.
Simplified
The global population is rapidly aging, presenting significant public health challenges, particularly with the increased risk of chronic diseases. refers to a faster-than-expected aging process, which is associated with an increased risk of age-related chronic diseases. Uric acid to high-density lipoprotein cholesterol ratio () is a novel biomarker that reflects metabolic disturbances and has been linked to various chronic conditions. Understanding the relationship between UHR and biological age acceleration, as well as its modifiable risk factors, is crucial for developing strategies aimed at promoting healthy aging and managing chronic diseases in older adults. Using data from a cohort study, the ratio of uric acid to high-density cholesterol (UHR), uric acid (UA), and high-density lipoprotein (HDL) were assessed in relation to biological age acceleration, including phenotypic age acceleration (PhAA) and Klemera-Doubal method age acceleration (KDM-AA), through multiple linear and logistic regression models, adjusted for demographic characteristics, lifestyle factors, and medical histories. Restricted cubic spline (RCS), subgroup, and interaction analyses were also conducted. Subgroups were stratified according to age (< 60 vs. ≥60 years), sex (male vs. female), race (Black vs. others), BMI (< 30 vs. ≥30), hypertension (yes/no), cardiovascular disease (yes/no), cancer (yes/no), and physical activity level (< 600, 600-3999, and ≥ 4000 min/week). The results reveal significant associations between elevated UHR, UA levels, reduced HDL cholesterol, and accelerated biological aging. RCS regression analyses revealed a complex relationship between UHR and age acceleration, with a non-linear association with PhAA and a linear relationship with KDM-AA. Subgroup analysis showed that the association between UHR and biological age acceleration remained robust across all groups. Interaction analyses revealed differential effects across subgroups, particularly among individuals with varying physical activity levels, cardiovascular disease, and hypertension status. This study demonstrates a significant positive association between UHR and markers of biological age acceleration. These findings suggest that UHR could serve as a potential biomarker for aging and chronic disease management in older adults, offering insights into strategies to reduce the burden of age-related conditions.
Key numbers
1.00
Increase in per unit
Model 3 adjusted for multiple covariates.
1.39
Increase in KDM-AA per unit
Model 3 adjusted for multiple covariates.
2.18
Increase in for highest tertile
Compared to lowest tertile.
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Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This research analyzed de-identified information downloaded from the National Health and Nutrition Examination Survey public database. The National Center for Health Statistics Ethics Review Committee granted ethics approval. All methods were carried out in accordance with relevant guidelines and regulations (declaration of Helsinki). All individuals provided written informed consent before participating in the study.
