Urinary 6-Sulfatoxymelatonin and Mammographic Density in Japanese Women

In a study of 289 Japanese women, urinary 6-sulfatoxymelatonin (aMT6-s) level was significantly positively associated with mammographic density in premenopausal women.

• Mammographic density is considered a marker of breast cancer risk.
• The study measured both the total breast area and the dense area using an automated detection method.
• In premenopausal women, a higher urinary aMT6-s level correlated with increased percent density after adjusting for other factors.
• No significant association was found between urinary aMT6-s level and mammographic density in postmenopausal women.
• The findings do not support the idea that melatonin levels are inversely associated with mammographic density.

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