Urine microRNA patterns closely predict biological age

Urinary microRNAs may provide a non-invasive clock for estimating biological age.

This machine-learning biomarker study used 6331 adults and reported independent-validation accuracy of MAE ≈ 4.4 years and R² ≈ 0.79.

The urinary clock was slightly less accurate than DNA-methylation clocks, and the abstract does not show that it predicts clinical outcomes.