USP22 may reduce aging in bone marrow stem cells caused by oxidative stress by keeping SPI1 protein stable

Bone marrow mesenchymal stem cell (BMSC) transplantation may be affected by oxidative stress-induced cellular senescence.

• Cellular senescence in BMSCs could reduce their effectiveness in therapeutic applications.
• Oxidative stress is associated with diminished osteogenic potential in BMSCs.
• The molecular mechanisms behind BMSC senescence remain largely unclear.
• Ubiquitin-specific peptidase 22 (USP22) may play a role in regulating oxidative stress-induced senescence in BMSCs.

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