Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide stimulate interleukin-6 production in prostate cancer cells and prostatic epithelial cells.

May 5, 2005Oncology reports

Two peptides increase inflammation-related protein production in prostate and prostate cancer cells

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Abstract

VIP stimulated the production of interleukin-6 (IL-6) in DU-145/AR prostate cancer and normal prostate epithelial cells.

  • VPAC1, VPAC2, and PAC1 receptor mRNAs were present in both prostate cancer cells and normal prostate epithelial cells.
  • PACAP also increased IL-6 production in normal prostate epithelial cells.
  • VIP enhanced IL-6 promoter transcriptional activity specifically in DU-145/AR prostate cancer cells.
  • VIP and PACAP may influence IL-6 production in normal and cancerous prostate cells.

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