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Abstract
A negative-feedback control mechanism involving transcription factors regulates peroxisome abundance during gut regeneration.
- Peroxisome dynamics are essential for intestinal stem cell differentiation and gut tissue repair.
- In mouse colitis and Drosophila intestine models, a feedback mechanism involving peroxisome proliferator-activated receptors (PPARs) and SOX21 was identified.
- Following gut injury, released free very long-chain fatty acids (VLCFAs) promote peroxisome abundance by activating PPARs-PEX11s signaling.
- PPARs facilitate peroxisome fission and suppress the process of peroxisome degradation (pexophagy).
- SOX21, which operates downstream of peroxisomes, triggers peroxisome degradation through pexophagy and inhibits PPAR expression.
- PPARs and SOX21 create a negative-feedback loop that precisely controls peroxisome dynamics during gut regeneration.
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