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Abstract
Gene therapies for glioblastoma may offer promising advancements in treatment options.
- Glioblastoma is a highly invasive brain tumor with a poor prognosis.
- Current treatments, including surgery, radiation, and chemotherapy, face resistance.
- Three viral gene therapies are evaluated: CRISPR-Cas9-mediated gene editing, suicide gene therapy, and oncolytic virus therapy.
- Preclinical challenges exist for these gene therapies, particularly related to biological and delivery barriers.
- Successful clinical translation may depend on optimizing these therapeutic approaches.
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