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Viral, Immunologic, and Laboratory Parameters in Patients With and Without Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Virus, immune response, and lab measures in people with and without long COVID
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Abstract
Of 57 eligible COVID-19 patients, 29 (51%) were identified as having post-acute sequelae of SARS-CoV-2 infection (PASC).
- PASC patients exhibited significantly higher nucleocapsid protein antigen levels 3 months post-COVID-19 diagnosis.
- Elevated levels of multiple cytokines, including IL-2 and IL-17A, were observed in PASC patients at 1 and/or 3 months after diagnosis.
- Median values of thyroid markers, autoimmune indicators, and stress-related hormones remained within normal ranges for both PASC and non-PASC groups.
- Findings suggest that PASC may be linked to prolonged immune dysregulation due to increased antigenic stimulation.
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Key numbers
29 of 57
PASC Prevalence
Patients diagnosed with PASC among total COVID-19 patients enrolled.
5.49 ng/mL
NP Antigen Level Increase
Median NP antigen level in PASC patients 3 months after diagnosis.
8
Cytokine Elevation
Number of significantly elevated cytokines in PASC patients at 1 and/or 3 months.